Anal cancer is a rare malignancy with approximately 5, new cases diagnosed annually in the United States. As a result of carefully conducted epidemiologic and clinical studies, it is now established that anal cancer is closely associated with human papillomavirus HPV infection. The cure of anal cancer is possible in the majority of patients with preservation of the anal sphincter. This malignancy has been historically treated by abdominoperineal resection, with associated high rates of morbidity and local recurrence. Pioneering work by Nigro a surgeon led to the discovery that radiation therapy combined with the drugs 5-fluorouracil 5-FU and mitomycin resulted in high rates of local control, disease-free, colostomy-free and overall survival without surgical intervention. Subsequent randomized trials Table I from Europe and the United States have shown the superiority of the combination of radiation therapy, 5-FU and mitomycin over a radiation therapy alone, b radiation therapy with 5-FU only and c a neoadjuvant approach of cisplatin or 5-FU alone followed by concurrent radiation, cisplatin and 5-FU discussed below.
Anal Cancer: What You Should Know - Callen-Lorde
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Anal Cancer: What You Should Know
Due to discrimination and stigma, there is a greater possibility that people at increased risk may neglect care. At Callen-Lorde, we are targeting our outreach efforts to screen all at-risk patients to detect anal cancer early while also working to improve the lives of our patients living with anal cancer. Anal cancer is a disease that is almost exclusively caused by a virus called HPV the Human Papillomavirus. Most sexually active adults have at least one strain of HPV and for many people, it causes no significant health issues. However, HPV has the potential to cause changes in the skin in a variety of vulnerable locations, including the anal canal.
Persons using assistive technology might not be able to fully access information in this file. For assistance, please send e-mail to: mmwrq cdc. Type Accommodation and the title of the report in the subject line of e-mail. ACIP also recommended vaccination with HPV4 for males aged 13 through 21 years who have not been vaccinated previously or who have not completed the 3-dose series; males aged 22 through 26 years may be vaccinated. ACIP recommends either vaccine for routine use in females aged 11 or 12 years 3.